| DATE | TYPE | AGAINST | Home Away | REFEREE | TV | TIME | SCORE | WIN Loss | |
| September 2011 | |||||||||
| Sat 3 Sep | PR | Newcastle Falcons | Away | Kingston Park | Martin Fox | 18:30 | 22-9 | WIN | |
| Sat 10 Sep | PR | Saracens | Home | Recreation Ground | Greg Garner | SKY | 15:15 | 26-28 | Loss |
| Sat 17 Sep | PR | Exeter Chiefs | Home | Recreation Ground | David Rose | ESPN | 17:30 | 23-19 | WIN |
| Sat 24 Sep | PR | Gloucester Rugby | Away | Kingsholm | JP Doyle | 15:00 | 23-6 | Loss | |
| October 2011 | |||||||||
| Sat 1 Oct | PR | Leicester Tigers | Home | Recreation Ground | Tim Wigglesworth | SKY | 15:15 | 26-25 | WIN |
| Sun 9 Oct | PR | London Wasps | Away | Adams Park | Andrew Small | 15:00 | 27-24 | Loss | |
| Sat 15 Oct | LVC | Newport Gwent Dragons | Away | Rodney Parade | Gwyn Morris | 14:30 | 16-46 | WIN | |
| Sat 22 Oct | LVC | Worcester Warriors | Home | Recreation Ground | Luke Pearce | 14:15 | 46-13 | WIN | |
| Sat 29 Oct | PR | London Irish | Away | Madejski Stadium | David Rose | ESPN | 14:30 | 12-13 | WIN |
| November 2011 | |||||||||
| Sat 5 Nov | PR | Harlequins | Home | Recreation Ground | Dean Richards | 14:15 | 13-26 | Loss | |
| Sun 13 Nov | EURO | Glasgow Warriors | Away | Firhill Arena | Christophe Berdos | SKY | 12:45 | 26-21 | Loss |
| Sun 20 Nov | EURO | Montpellier | Home | Recreation Ground | Alain Rolland | SKY | 15:00 | 16-13 | WIN |
| Fri 25 Nov | PR | Worcester Warriors | Away | Sixways | Martin Fox | 19:45 | 16-7 | Loss | |
| December 2011 | |||||||||
| Sat 3 Dec | PR | Sale Sharks | Home | Recreation Ground | JP Doyle | 14:15 | 13-16 | Loss | |
| Sun 11 Dec | EURO | Leinster | Home | Recreation Ground | Jérôme Garces | SKY | 12:45 | 13-18 | Loss |
| Sat 17 Dec | EURO | Leinster | Away | Aviva Stadium | Romain Poite | SKY | 18:00 | 52-27 | Loss |
| Sat 24 Dec | PR | Northampton Saints | Away | Franklin's Gardens | David Rose | 15:15 | 22-13 | Loss | |
| January 2012 | |||||||||
| Sun 1 Jan | PR | London Irish | Home | Recreation Ground | Martin Fox | 13:30 | 30-3 | WIN | |
| Sun 8 Jan | PR | Saracens | Away | Vicarage Road | Pascal Gauzere | 15:00 | 26-19 | Loss | |
| Sat 14 Jan | EURO | Montpellier | Away | Stade Yves Du Manoir | Dudley Phillips | 15:00 | 24-22 | Loss | |
| Sat 21 Jan | EURO | Glasgow Warriors | Home | Recreation Ground | Christophe Berdos | 14:15 | 23-18 | WIN | |
| Sat 28 Jan | LVC | Northampton Saints | Home | Recreation Ground | Sean Davey | 14:30 | 46-14 | WIN | |
| February 2012 | |||||||||
| Sun 5 Feb | LVC | Exeter Chiefs | Away | Sandy Park | SKY | 17:00 | |||
| Sat 11 Feb | PR | Newcastle Falcons | Home | Recreation Ground | 14:15 | ||||
| Sat 18 Feb | PR | Gloucester Rugby | Home | Recreation Ground | 14:30 | ||||
| Sat 25 Feb | PR | Exeter Chiefs | Away | Sandy Park | 18:00 | ||||
| March 2012 | |||||||||
| Sat 3 Mar | PR | Worcester Warriors | Home | Recreation Ground | 14:15 | ||||
| Sat 24 Mar | PR | Harlequins | Away | Twickenham Stoop | 14:15 | ||||
| Sat 31 Mar | PR | Northampton Saints | Home | Recreation Ground | 14:15 | ||||
| April 2012 | |||||||||
| Fri 13 Apr | PR | Sale Sharks | Away | Edgeley Park | 19:45 | ||||
| Sat 21 Apr | PR | London Wasps | Home | Recreation Ground | 14:15 | ||||
| May 2012 | |||||||||
| Sat 5 May | PR | Leicester Tigers | Away | Welford Road | 15:00 | ||||
F Friendly
PR Aviva Premiership
EURO European Cup
LVC LV= Cup